Common Problems. Phytother Res 2011;25:88-91) ~ Fenugreek has been shown to increase the production of milk in nursing mothers (Forinash, A. Much research on fenugreek has been conducted in India and other countries, focusing on its potential for the treatment of diabetes. Studies in patients with type 2 diabetes and hypercholesterolemia have used from 1 g/day of a hydroalcoholic extract of fenugreek up to 100 g/day of germinated fenugreek seeds, whereas seed powder 1.8 to 2.7 g taken 3 times daily for the first 3 days of menstruation was used in primary dysmenorrhea (total daily dose, 5.4 to 8.1 g); 500 mg twice daily of a standardized extract was studied for management of postmenopausal symptoms. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Anti-inflammatory, antioxidant, and cytotoxic properties have yet to be fully explored. Cross-reactivity to legumes is possible; consider allergy potential with chickpea, peanuts, soybeans, lentils, lupin, green peas, or coriander. You can also know the Fenugreek Scientific Classification which will help you gain the botanical information about the plant. It develops over time, according to use, look, and lore. Animal studies have demonstrated abortifacient effects in females and antifertility effects in males and females; whereas congenital malformations have been observed in humans as well as animals. Each pod contains about 10 to 20 small, yellowish-brown, angular seeds, which are dried to form the commercial spice. Liver transplant was also more frequent with toxicity from non-bodybuilding supplements (13%) than with conventional medications (3%) (P<0.001). It is used both as an herb, from the leaves of the plant, and as spice, from the seeds. The plant bears grey-green, tripartite, toothed leaves, and white or pale yellow flowers appear in summer and develop into long, slender, sword-shaped seed pods with a curved, beaklike tip. Common effective dosages are around 1000mg. Common Names. Fenugreek is used as an ingredient in spice blends and a flavoring agent in foods, beverages, and tobacco. Historically, Fenugreek was used mostly for therapeutic purposes. Isolation of the biologically active components or production of a more palatable extract, which would allow greater use of the plant, have been investigated.3, Suppression of interleukin production and allergic symptoms were demonstrated in rats pretreated with fenugreek extracts.12, 13, 14 Inhibition of the arachidonic acid pathway was demonstrated in mice,15 and studies in rats with induced arthritis have found positive effects on erythrocyte sedimentation rate, total white blood cells, and C-reactive protein.14, 16, There are very limited clinical data regarding the use of fenugreek as an anti-inflammatory agent. A Cochrane systematic review and meta-analysis of dietary supplements for dysmenorrhea identified only low or very low quality studies with very small sample sizes. Fenugreek also known as Methi in Hindi, has its botanical name as Trigonella Foenum-Graecum. Fenugreek has been documented to have uterine stimulant effects and has been used in traditional medicine to induce childbirth. Avoid if an allergy to any member of the Fabaceae family exists. Last updated on Dec 20, 2018. The common name of this plant in Spanish is Fenogreco. Standardization of seed content has been reported on.4, 5, 6, 7, 8. The maple aroma and flavor of fenugreek has led to its use in imitation maple syrup. Studies have demonstrated the cholesterol-lowering activity of fenugreek in animals, including rats and dogs.17, 35, 36, 40, 45, 46, A systematic review identified 5 clinical trials before 2003 that investigated the cholesterol-lowering effects of fenugreek seeds. In the botany, fenugreek is a small annual leguminous herb belonging in the Fabaceae family, genus: Trigonella. The slightly bitter, spicy taste to the leaves tends to deter varmints and deer. In another study, micturition and dizziness were reported within 24 hours of acute administration of a 40 mg/kg single dose of aqueous leaf extract.90 A trial evaluating the safety of a standardized hydroalcoholic extract of fenugreek seeds at a dosage of 300 mg twice daily over 6 months reported no hematological or biochemical effects, including effects on liver and kidney function tests, over placebo.33 In contrast, animal studies have repeatedly documented histopathological and hematological changes in the liver and kidney.90, Fenugreek should be used with caution in individuals taking thyroid hormones because animal studies suggest that it may alter T3 and T4 levels.66, 67, Allergy to fenugreek is recognized; asthma, rhinitis, sneezing, excessive tearing, bronchospasm, numbness of head, facial angioedema, wheezing, and toxic epidermal necrolysis have been documented in several case reports. Neither dose produced a significant reduction in postprandial blood glucose.76, A systematic review and meta-analysis identified 10 clinical trials that evaluated the effect of fenugreek intake on glucose homeostasis markers including fasting blood glucose, 2-hour postload glucose, HbA1c, and fasting serum insulin levels. Fenugreek, Alhova, Bird's Foot, Greek Clover, Greek Hay, Hu Lu Ba, Methi, Trigonella Low to moderate doses have been shown to produce mild CNS stimulation in rats with higher doses producing twitches, tremors, painful stimuli, and generalized convulsions.90, Data collected between 2004 and 2013 among 8 US centers in the Drug-induced Liver Injury Network revealed 15.5% (130) of hepatotoxicity cases was caused by herbals and dietary supplements whereas 85% (709) were related to medications. Three minor steroidal sapogenins, smilagenin, sarsasapogenin, and yuccagenin, also have been found in the seeds.9, 10 The lactone sotolone is responsible for the plant's characteristic smell. Alternate Names Fenugreek is also known as Methya (in Marathi), menthya (in Kannada), Vendayam (in Tamil), Menthulu (in Telugu), Uluva (in Malayalam) , Uluhaal ( in Sinhalese), Methi ( (In Oriya,Bangla, Punjabi, Urdu and Hindi). The primary inclusion criterion was last menses between 12 months and 3 years; although, the authors noted ambiguously that the last menstrual period in participants of both groups was noted to have occurred before 12 months. Fruits + Chicago Hardy Fig. Additionally, effects of fenugreek on lipid parameters were assessed and the pooled data revealed a significant decrease with fenugreek on triglycerides (−0.27 mmol/L; P=0.01) and total cholesterol (−0.30 mmol/L; P=0.03). Sample sizes ranged from 5 to 69 and most trials included patients with type 2 diabetes. Learn more about Fenugreek uses, effectiveness, possible side effects, interactions, dosage, user ratings and products that contain Fenugreek Fenugreek may lower blood glucose and cholesterol levels in people with diabetes. The use of fenugreek dates back to around 4000 BC. It’s a common ingredient in Indian dishes and often taken as a supplement. Fenugreek supplements do not have a specific dosage range that is known to be more effective. Fenugreek showed greater efficacy than placebo, but further, larger trials are required to determine if fenugreek has a place in the treatment of Parkinson disease.33 A double-blind, placebo-controlled trial found clinically significant beneficial changes in total and motor UPDRS scores as well as H & Y staging for 42 early Parkinson patients taking 300 mg twice daily of a standardized fenugreek extract for 6 months as a nutritional adjuvant to levodopa/carbidopa therapy.82, The galactomannan-rich soluble fiber fraction of fenugreek may be responsible for the antidiabetic activity of the seeds.3 Insulinotropic and antidiabetic properties also have been associated with the amino acid 4-hydroxyisoleucine, which occurs in fenugreek at a concentration of about 0.55%. Trees-Acacia. Monitor therapy.61, 62, 63, 78, Fenugreek is generally recognized as safe for use both as a spice and as a fiber. It has also has been recommended for the promotion of lactation. A clinical trial evaluated the effects of fenugreek fiber 4 and 8 g at breakfast in adult non-diabetic patients with a body mass index of 30 or higher. Delayed gastric emptying and inhibition of glucose transport have also been postulated as possible mechanisms, as well as restoration of enzymes involved in glycolysis and gluconeogenesis.8, 34 Hypoglycemic effect appears greatest for fenugreek whole seed powder, with lesser effect for the gum isolate, other seed extracts, and leaves.35, Reports of experiments in animals from the 1980s and 1990s have been published,35, 36 and studies to elucidate the mechanisms of action of fenugreek in diabetes are ongoing.37, 38, 39, 40, 41, 42, A lack of standardization of products tested and dosages used limits the value of the limited published clinical trials. Imitation maple syrup for pre-diabetes limited the usefulness of disease subgroup analysis sourcing for it more easy for.. 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